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"Longevity Gene Therapy" refers to the use of genetic interventions aimed at extending lifespan and promoting healthy aging. Scientists are exploring various genes and genetic pathways associated with longevity in hopes of developing therapies that could potentially slow down aging-related processes and increase lifespan.
One of the most widely studied genes in this context is the Sirtuin gene family, particularly SIRT1. Sirtuins are a class of proteins that play roles in regulating cellular processes like metabolism, DNA repair, and inflammation, which are all implicated in aging. Activation of SIRT1 has been linked to longevity in various model organisms, although its effects in humans are still under investigation.
Another promising area of research involves genes related to pathways such as insulin and insulin-like growth factor (IGF-1) signaling, which have been implicated in the regulation of lifespan in several species.
Additionally, research into gene editing technologies like CRISPR-Cas9 has opened up new possibilities for targeted interventions to modify genes associated with aging and longevity. However, ethical considerations and safety concerns remain significant hurdles in the development and application of gene therapies for extending lifespan in humans.
While significant progress has been made in understanding the genetic basis of aging and longevity, much more research is needed before longevity gene therapies become a practical reality for widespread use in humans.